Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity.

In the livers of immunized DRAGA mice the mean average number of human CD4 and CD8 T cells was reduced (1.8 and 2.6 fold, respectively) and the mean average for human B cells was increased (2.5 fold) as compared to livers of control DRAGA mice, though the results did not reach statistical significance (Fig. 1 a, right panels).

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