Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE^-/- Mice Following Regular Exposure to Cigarette Smoke.

The difference in lung vasculature collagen content did not reach statistical significance for treated mice compared to untreated animals although vascular collagen content was substantially lower in mice that received endothelial cell targeted MMP-9 specific siRNA ( Figure 7 b).

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