IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway.

Oncogene · 2018 · PMC5861089 · PMID 29238040

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quite significantno p-value reported

This may well be quite significant as an efficient blood supply is required for cancer cells to grow beyond a critical mass and progress to a malignant phenotype [ 46 , 47 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.