The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker.

There was a similar upward trend of mean sTLR2 levels in the serum samples of RRMS patients (0.907 ng/ml) compared to HC (0.836 ng/ml) and the values were almost in the same concentration range as in the discovery data set although it did not reach statistical significance ( P = 0.6061) (Figures 2 A,B).

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When we pooled the data from two cohorts, however, statistical differences between the RRMS ( n = 41) and HC ( n = 44) groups were highly significant (Figure 2 C).

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