Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity.

Arthritis Res Ther · 2018 · PMC5863797 · PMID 29566725

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showed a trendno p-value reported

Previous studies showed that upregulation of genes encoding negative regulators of innate immunity, such as IL-10 [ 39 ], IL-1 receptor antagonist, and SOCS3 [ 52 ], were elevated in patients with active AOSD, and IL-10 showed a trend similar to that of the AOSD disease activity [ 53 ].

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