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A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.

BMC Genet · 2018 · PMC5865342 · PMID 29566674

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The other SNPs that did not reach statistical significance in this study and that were not replicated in our previous association study of CM in GB dogs require further genetic analyses in larger cohorts.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.