Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

Additionally, for CYP19A1 SNPs, there were indications of associations with testosterone in the opposite direction compared with E2, but these associations did not reach statistical significance (rs727479 P = 0.05 and rs16964258: P = 0.26) ( Table 2 ; Fig. 2 ).

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