Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.

Mol Metab · 2018 · PMC5870102 · PMID 29398615

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Isolated mitochondria from IGFR-KO astrocytes showed a trend towards a decrease in oxygen consumption rate (OCR; Figure 4 A), as well as OXPHOS coupling efficiency ( Figure 4 B), which is a measure of the efficiency of the ETC to generate ATP, compared to control (GFP) astrocytes.

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