A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction.

Mol Metab · 2018 · PMC5870107 · PMID 29398618

Europe PMC DOI

hedged sentence

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

approached significancep = 0.066so close (0.05 < p ≤ 0.1)

To confirm that 4-HNE can activate p53 in adipocytes, we found that incubation of 3T3-L1 adipocytes for 6-hours with 4-HNE increased Cdkn1a mRNA levels 2.9-fold (p = 0.003) and Igfbp3 mRNA expression approached significance (p = 0.066), consistent with downstream p53 activation [ Figure 6 F].

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