Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

In contrast cg27411982 was still nominally significant even after the addition of 12 ASD-associated SNPs, four of which were independently associated and largely explained the association between the ASD PRS and DNA methylation (Additional file 1 : Figure S20; Additional file 2 : Table S10).

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We identified a highly significant association between this smoking score and actual exposure, with offspring exposed to tobacco smoking in utero having higher smoking scores compared to offspring who were not exposed ( P = 8.41 × 10 −95 ; Fig. 1c ) [ 23 , 34 ].

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