Early-Life Cognitive Activity Is Related to Reduced Neurodegeneration in Alzheimer Signature Regions in Late Life.

Front Aging Neurosci · 2018 · PMC5875443 · PMID 29623037

Europe PMC DOI

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closest p · 0.8× alpha

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a decreasing trendP = 0.04actually significant

Higher early-life CA (CA early ) was associated with significantly increased AD-CMglu ( B = 0.035, SE = 0.013, P = 0.009) and a decreasing trend of AD-ND positivity (OR = 0.65, 95% CI 0.43–0.98, P = 0.04) but was not associated with Aβ deposition or positivity.

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showed a trendno p-value reported

Although not statistically significant, CA late showed a trend association with global Aβ deposition and AD-CMglu.

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