The mean level of NADP + also increased, but did not reach statistical significance (mean change = 1.2 pmol per mg protein; one-sided 95% CI (−2.15, ∞)) (Fig. 2 and Table 3 ).
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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD<sup>+</sup> in healthy middle-aged and older adults.
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