15 There were modest decreases in mortality rates but they did not reach statistical significance. 15 A subsequent meta-analysis of 3723 patients comparing 90-day mortality between EGDT and usual care in a sicker cohort then prior studies also failed to find a benefit. 14 In addition, although EGDT was not harmful, it was associated with higher costs. 14 With the increasing literature demonstrating a more modest to no effect of EGDT, 14 the SSC has continued to evolve in the components encompassed in the endorsed sepsis treatment bundles.
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