miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.

In these individuals, associations between miR‐424‐5p expression in the quadriceps and reduced physical performance measured as both 6 m TUG and 3 m gait speed did not reach statistical significance ( r = 0.23, P = 0.066 and r = 0.23, P = 0.069, respectively, Figure 5 ), nor was there any association of the miRNA with FFMI, but miR‐424‐5p expression was higher in those defined as sarcopenic by the European Working Group on Sarcopenia in Older People criteria ( P = 0.01) than in non‐sarcopenic individuals ( Figure 5 ).

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