The highly abundant phosphatidylinositol 38:4, phosphatidylcholine 34:1, and phosphatidylethanolamine 34:1 species were also reduced in nerves of FASN mutant mice, whereas the most abundant phosphatidylethanolamine, 36:2, showed a trend toward reduction ( Fig. 5 d and Fig.
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De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.
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