Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese.

In the analysis of genotypes A and B, there were no significant differences in other baseline characteristics including age, total cholesterol levels, low-density lipoprotein and high-density lipoprotein cholesterol levels, triglyceride levels, and BMI, except for the fasting plasma glucose level which was higher with borderline significance in genotype B.

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When BP levels were divided into categories (< 120, 120–139, and ≥140 for the systolic BP and <80, 80–89, and ≥90 for the diastolic BP), there was also a significant trend toward a higher prevalence of the combined genotypes in the highest systolic and diastolic categories; 0.6% versus 3.3% versus 11.4% ( P for trend = 5.93 × 10 −5 ) and 1.1% versus 1.3% versus 14.7% ( P for trend = 3.75 × 10 −4 ), respectively [ Figure 1 ].

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