The long non-coding RNA <i>HOTAIR</i> is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma.

While HOTAIR and HOXA9 co-expression did not reach statistical significance for grade II gliomas ( n = 6; Supplementary Figure 2A ), this is likely due to the small sample size, and the same trend for co-expression was observed; indeed, all of these tumors were either double-positive or double-negative (Table 1 ).

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