Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial.

JAMA Neurol · 2018 · PMC5885221 · PMID 29507944

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showed a trendno p-value reported

In addition, a large trial on SVD showed a trend toward reduced recurrent stroke with intensive BP lowering. 12 However, many patients in that study had isolated lacunar infarction without WMHs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.