COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.

In an additional Model 4, we show that adding COPD to the model did not change the effect of rs7937 on DNA methylation ( Supplementary Material , Table S1). COPD and FEV 1 /FVC analyses When testing for association of DNA methylation at the four replicated differentially methylated CpG sites with COPD, we observed a significant association with cg11298343 ( EGLN2 ) in Model 1 [ β (SE)=−7.080 (2.16), P = 0.001] ( Table 3 , Supplementary Material , Table S2), which remained nominally significant with diminished but still strong and concordant negative effect, after adjusting for smoking [Model 2; β (SE) = −4.924 (2.25), P = 0.029].

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