Accumulation was well described, but a visual predictive check (VPC) indicated a small trend of increased exposure with time from cycle 3 onwards that was not fully captured by their linear clearance model predictions.
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Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status.
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The sentences
By visual inspection, longitudinal data of LDH, neutrophil‐to‐lymphocyte ratio (NLR), albumin (ALB), and tumor size all showed a trend over time ( Figure 2 ).