There was a clear trend between increased interstitial inflammation grade and elevated serum creatinine in patients with Class IV ( Supplementary data , Table S3; Class IV with interstitial inflammation <5%, 1.41 mg/dL; interstitial inflammation 5–25%, 1.44 mg/dL; interstitial inflammation 25–50%, 2.00 mg/dL; interstitial inflammation >50%, 2.37 mg/dL; F = 2.8, P = 0.047).
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Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis.
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