XPAT: a toolkit to conduct cross-platform association studies with heterogeneous sequencing datasets.

Notably, though we observed attenuation of the signal after excluding LGD variants, five gene–cancer associations remained nominally significant ( P < 0.05): BRCA1, BRCA2, RAD51B and CHEK2 in breast cancer and BRCA1 in ovarian cancer, (Figure 4 and Supplementary Table S8 ).

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