Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML).

J Transl Med · 2018 · PMC5892020 · PMID 29631596

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0800

boldest claim

The sentences

showed a trendP = 0.073so close (0.05 < p ≤ 0.1)

As compared with rs3760468 AA homozygotes, rs3760468 TT homozygotes showed significantly worse OS (TT vs AA, HR = 1.652, 95% CI 1.067–2.557, P = 0.024) and carriers of the rs3760468 T allele showed a trend of worse OS (TT+AT vs AA: HR = 1.328, 95% CI 0.973–1.812, P = 0.073).

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marginally significantP = 0.080so close (0.05 < p ≤ 0.1)

Marginally significant difference in OS between the RRM2 rs1130609 GG and GT+TT genotypes was also observed (HR = 1.516, 95% CI 0.948–2.422, P = 0.080, Table 6 ).

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