Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.

Among the correlations of gene expression levels with APOBEC-like motif counts and measures of kataegis, significant or nearly significant correlations were observed for UNG expression with kataegis measures ( ρ between − 0.81 and − 0.80, 0.039 ≤ p adj ≤ 0.063, n = 17, N tests = 475) of the T(C>D)D motif in melanoma, and for APOBEC3A expression with motif counts and kataegis measures in renal cell carcinoma ( ρ between 0.93 and 0.98, 0.008 ≤ p adj ≤ 0.087 with n = 8 and N tests = 510 for the T(C>D)R and T(C>D)D motifs; data not shown).

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