Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor.

Although the highly significant cancer signature was expected, the melanoma signature was not, given that CTVT has been proposed have a histiocytic origin ( Cohen, 1985 , Mozos et al., 1996 ).

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It is notable that the non-regressing CTVT-6 showed a trend toward re-methylation in the last biopsy, which suggests that the demethylation of upregulated genes needs to be maintained over time for successful regression.

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