Barely Significant
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Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1).

Nicotine Tob Res · 2018 · PMC5896533 · PMID 28177489

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a clear trendno p-value reported
Despite the high variability associated with the Ames test, there was a clear trend in the decrease in carcinogens of tobacco smoke after switching to mTHS as compared with those continuing mCC, with a similar trend in the SA group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.