Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.

We find nominally significant evidence for concordance between the direction of effect at previously reported osteoarthritis loci and the discovery analyses for hospital diagnosed osteoarthritis definitions ( Supplementary Table 6, Supplementary Table 7, Supplementary note ), indicating that a narrower definition of disease may provide better effect size estimates albeit limited by power to identify robust statistical evidence for association.

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