When treating WT mice, the CDN pretreatment and two-time post-treatments showed significantly improved survival as compared to non-treated controls, and the one-time post-treatment group suggested improved survival, but the data did not reach statistical significance (p = 0.06) ( Fig 4B ).
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STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice.
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