Improvement of treatment outcome over 2 decades in children with acute myeloid leukemia.

The annual numbers of newly diagnosed AML cases showed a decreasing trend over 2 decades, probably due to reduced childhood population ( Fig. 2 ).

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These results did not reach statistical significance probably due to the small number of patients in the adverse cytogenetics group (N=11), and biasing of these patients toward treatment with HSCTs.

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