Pretreatment rate of decay in forced vital capacity predicts long-term response to pirfenidone in patients with idiopathic pulmonary fibrosis.

Among slow progressors, the reduction of the annual FVC decline compared to the pretreatment period did not reach statistical significance at any of the time points examined, i.e. at 6 months (T6) (49 ml/year, 0% pred. vs. 141 ml/year, 3% pred. pretreatment, p = 0.3) nor in any of the other follow-up time points (34 ml/year, 1% pred. at 12 months; 67 ml/year, 3% pred. at 18 months; 78 ml/year, 1% pred. at 24 months) (p value for trend from T6 to T24 n.s.) (Fig. 1C ).

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