Age-associated changes in the blood-brain barrier: comparative studies in human and mouse.

Results Quantification of the tight junction protein ZO ‐1 within the cortex and cerebellum of the mouse cohort showed a significant trend to both increased number (cortex P < 0.001, cerebellum P < 0.001) and length (cortex P < 0.001, cerebellum P < 0.001) of junctional breaks associated with increasing age.

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Using more rigorous quantitative analysis of the tight junction protein ZO‐1, we demonstrate a highly significant increase in BBB breaks throughout the life of our mouse cohort.

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