Upon addition of curcumin- β - d -glucuronide substrate the effect of released curcumin on cell viability was assessed over 48 h as a marker for therapeutic efficiency of our gels, a standard method to assess curcumin’s inflammation modulation both in vitro and in vivo.[ 8 , 19 ] We observed a significant or a near-significant antiinflammatory response for EV- and lipo-glucuronidase, and free glucuronidase gels compared to control gels ( Figure 3a ).
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Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy.
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