Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry.

Discussion Replacement of the acetate with amide groups in the pendant arms of DOTPI does not affect the thermodynamic stability (log K ML values) of the Ca II -, Zn II -, and Cu II -complexes, while dissociation half-lives of the Cu II chelates at pH > 3 show a clear trend toward higher kinetic inertness.

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