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Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

Nat Commun · 2018 · PMC5902554 · PMID 29662056

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Analysis of plaque-associated microglia revealed an increased proportion of cells containing phagolysosome-encapsulated Aβ in SphK1-overexpressed APP/PS1 mice, although this trend did not reach statistical significance.

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