Incidence of metastasis and prostate-specific antigen levels at diagnosis in Gleason 3+4 versus 4+3 prostate cancer.

We found that patients with GS4+3 prostate cancer were more likely to present with higher incidence of distant metastasis at the time of diagnosis, had higher PSA levels and experienced a 23% reduction in overall survival, although the survival difference did not reach statistical significance.

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