STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.

PLoS Pathog · 2018 · PMC5908086 · PMID 29630659

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a clear trendno p-value reported

A clear trend was evident showing an abundance of STAT3 protein and increased levels of STAT3 phosphorylation in high-grade HPV lesions compared to low-grade lesions, or control cervical samples.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.