DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Ann Rheum Dis · 2018 · PMC5909746 · PMID 29437559

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highly significantno p-value reported

33 We further identified highly significant novel DMCs in SLE at the genes adenylate kinase 2 ( AK2 ) playing a role in apoptotic processes and activating signal cointegrator 1 complex subunit 2 ( ASCC2 ) involved in transcriptional regulation.

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nominally significantno p-value reported

However, the majority of the observed DMCs in SLE were nominally significant also in the group of patients not treated with glucocorticoids.

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