Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The effects on IL-6 did not reach statistical significance (MD, −0.10 pg/mL; 95% CI, −0.25 to 0.05; P =0.2, I 2 =21%) ( Fig. 7 ), but TNF-α levels significantly reduced (MD, −1.71; 95% CI, −3.38 to −0.14; P =0.03, I 2 =86%) ( Fig. 8A ), this effect also remained after removing Spencer et al.

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