Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels.

PLoS One · 2018 · PMC5919616 · PMID 29698514

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

near-significantp = 0.055so close (0.05 < p ≤ 0.1)

Longer (7-day) stimulation with MPA increased expression of the activation marker CD69 in CD4+ T-cells, with a near-significant increase (p = 0.055) in CD69+CD4+ T cell frequency, indicating increased activation of CD4+ T-cells.

also in 2,306 other papers

an increasing trendno p-value reported

showed an increasing trend for both activation and CCR5 density for CD4+ T-cells in PBMCs from women on DMPA-IM [ 9 ], consistent with our MPA results.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.