Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability.

Confirming and extending these observations, we found that proteins associated with aneuploidy-induced stress responses showed a trend toward up-regulation in all cell lines that had undergone major chromosome gains, notably the 4N clone and the PTA clones (Supplemental Figure S3A).

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Only few processes, including protein sumoylation and G-protein coupled receptor signaling, showed highly significant GO-term enrichments in clones displaying CIN (Supplemental Figure S5A).

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