Interestingly, a marked trend of a higher colony number in soft agar in CD70-positive (CD70 + ) cells compared to CD70-negative (CD70 – ) was identified in 9 ovarian, 5 lung, 2 kidney and 2 brain cancer cell lines in soft agar assays (Table 1 ).
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells.
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