Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction.

Mitochondrial coupling was decreased in ob/ob AMLN mice compared to mitochondria from lean mice (4.2 vs 5.6; Figure 5C ), although this difference did not reach statistical significance. ob/ob AMLN mitochondria also displayed a higher LCR compared to lean controls (0.35 vs 0.23, P = 0.06; Figure 5D ), indicating increased proton leak.

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While no FDA-approved pharmacotherapies for NAFLD/NASH currently exist, more than 100 clinical trials are now targeting this highly significant unmet medical need.

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