Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies.

BMC Cancer · 2018 · PMC5924486 · PMID 29703161

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

trend toward significanceP = 0.055so close (0.05 < p ≤ 0.1)

There was trend toward significance for treatment with anti-PD-1 antibody ( P = 0.055 ).

also in 304 other papers

showed a trendno p-value reported

Intriguingly, of factors in the primary tumor, increased levels of tumor-infiltrating lymphocytes showed a trend toward improved survival in patients with brain metastasis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.