Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors.

Onco Targets Ther · 2018 · PMC5931236 · PMID 29740211

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did not reach statistical significanceno p-value reported

Studies showed that for HPV-positive OPSCC, the difference between the hazard ratios for primary surgery and primary radiation did not reach statistical significance, while worse outcomes were associated with HPV-negative OPSCC when it was treated with primary radiation as compared to treatment with surgery. 15 , 21 Therefore, evaluation of surgical management for HPV-negative OPSCC is of vital importance.

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