Spatiotemporal assessment of spontaneous metastasis formation using multimodal in vivo imaging in HER2+ and triple negative metastatic breast cancer xenograft models in mice.

In the same time interval, an increase in BLI signal from the rest of the mouse as measure for development of metastasis ( Fig 2E ) was observed for LM2-4 (day 7.5: 3.8x10 6 ± 6.8x10 6 p/s, n = 12; day 21: 1.2x10 8 ± 1.4x10 8 p/s, n = 10; P = 0.03, t -test), but did not reach statistical significance for LM2-4H2N (day 7.5: 3.1 x10 6 ± 4.3 x10 6 p/s, n = 11; day 21: 8.0x10 7 ± 1.1x10 8 p/s, n = 10; P = 0.05, t -test).

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