Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

Nat Commun · 2018 · PMC5934419 · PMID 29725062

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a clear trendp < 10 −6actually significant

Overall, both Hsp90 N and hsp90 i populations demonstrate a clear trend to generally optimize overall codon usage to match that of the host-cell (Fig. 5b ; Hsp90 N : p < 10 −6 by MWW test; hsp90 i : p < 10 −6 ; Supplementary Fig. 6a,b ).

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