Barely Significant
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The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

Sci Rep · 2018 · PMC5935702 · PMID 29728633

Europe PMCDOI
1
hedged sentence
0.0072
closest p · 0.1× alpha
0.0072
boldest claim

The sentences

nominally significantp = 7.2 × 10 −3actually significant
Notably, after 4 hours of IL-12 treatment, the most significantly up-regulated gene was IL18RAP (average 2.37-fold, FDR p = 1.0 × 10 −13 ), which also manifested a nominally significant effect of TYK2 genotype (ANOVA p = 7.2 × 10 −3 , Table S10 ).

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