Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Cell · 2018 · PMC5938365 · PMID 29656895

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

did not reach statistical significancep=0.01actually significant

The association with ITH did not reach statistical significance, however we note that "low ITH, high wGII" tumours were linked to rapid progression in the larger cohort (p=0.01, Turajlic et al., 2018a ).

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a trend towards significanceno p-value reported

Loss of 14q also showed a trend towards significance, and taken together these two events represent hallmark genomic alterations in ccRCC metastasis (overall 36 of 38 TRACERx Renal cases had loss of at least one of these chromosome arms).

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