10 μm pravastatin caused a significant increase in cPARP (p<0.001) compared to controls, which was prevented by co-treatment with 10 μM FPP, while 1 μM FPP showed a trend towards decreased PARP cleavage ( Fig 6D and 6E ).
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Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms.
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Of the top 10 identified upstream regulators, SCAP (p = 1.25x10 -45 ), INSIG1or2 (p = 8.06x10 -37 & p = 4.96x10 -17 , respectively), and SREBP2 (p = 1.47x10 -16 ) were all found to be highly significant ( Fig 5A and 5B ).