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PI(4,5)P<sub>2</sub> controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.

J Cell Biol · 2018 · PMC5940310 · PMID 29472386

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Combined knockdown of ORP5/8 consistently slowed down the rate of PI4P clearance after blocking PI4P production by A1 treatment, although this effect did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.